Jaundice revealing hyperthyroidism : About one observation in National Hospital Center of Nouakchott.

Abstract

Introduction : liver damages during hyperthyroidism are miscellaneous and of unexplained pathophysiology beyond those observed in cardiothyreosis or related to treatment. This observation describes a plain jaundice case during hyperthyroidism. Observation: She is a 60 year old patient, she is balanced diabetic under hygienic dietary measures alone. She came due to an unencrypted significant weight loss and physical fatigue. Medical examination revealed jaundice and tachycardia. Biology showed: glucose 1.16 g/l, HbA1c 6.2 %, total bilirubin to 66 μmols/l, conjugate bilirubin to 53 μmols/l, free bilirubin to 13 μmols/l. The thyroid examinations showed: TSHus <0.005 mIU/l, free FT4 42.4 pmols/l, anti‑TPO Ac 1268 IU/l (N < 12), anti‑thyroid Ac 8 IU/l (N < 35) . Abdominal ultrasound was within standards. Jaundice vanished and bilirubin came back to the standards after a month under Carbimazole 50mg/day. Conclusion: Intrahepatic cholestasis is not scarce during hyperthyroidism. It should be sought for before an unexplained cholestasis.