Comparative study of clinical efficacy between amniotic membrane transplantation and conjunctival flap covering surgery in the treatment of corneal ulcers about 36 cases in CHN.

Abstract

AIM : To provide evidence for Evidence‑Based Medicine on clinical treatment of corneal ulcers by analyzing the clinical ef icacy between amniotic membrane transplantation and conjunctival lap covering surgery ; in addition, to explore the different surgical adaptabilities for each treatment of corneal ulcers. METHODS : This retrospective review comprised 36 cases of corneal ulcers patients (36 eyes) whohad had amniotic membrane transplantation or conjunctival lap covering surgery from October 2018 to July 2019. All the patients were treated with removal of the necrotic corneal tissue combined with amniotic membrane transplantation or conjunctival lap covering surgery and then were treated with drugs based on primary disease. RESULTS : 17 cases (17 eyes)were treated with amniotic membrane transplantation and 19 cases (19 eyes) were treated with conjunctival lap covering surgery. They include 8 cases (8 eyes) with viral corneal ulcer, 9 cases (9 eyes) with fungal corneal ulcer, 3 cases (3 eyes) with bacterial corneal ulcer, 3 cases ( 3 eyes) with erosion and marginal corneal ulcer, 4 cases (4 eyes) with corneal epithelial bullae and ulcers for corneal endothelial decompensation caused by optical surgery 9 cases (9 eyes with perforation). 13 cases (13 eyes) treated with amniotic membrane transplantation were cured with a cure rate of 76.5% (13/17), 14 cases (14 eyes) treated with conjunctival lap covering surgery were cured with the cure rate at 73.7% (14/19). Discussion : Both procedures were easy to do but the clinical cure rates between the 2 procedures were of no signi icant difference (P>0.05). Conclusion : Amniotic membrane transplantation and conjunctival lap covering surgery in the treatment of corneal ulcers can achieve better surgical treatment if appropriate surgical method is selected according to different types and different ulcer process